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| Product Condition: | Sealed By no means open, By no means used |
|---|---|
| Category: | Whight Loss |
| Payment Mode: | Cash On Delivery, Bank Transfer |
| Delivery Time: | 1 To 2 Days |
Max Slim 7 Days weight Loss In Pakistan | Shop Now A wide variety of illicit, weight-reducing agents has been discovered in proprietary slimming products that are readily available to the public. Most importantly, ingestion of these products may lead to significant toxicities and even mortality (1, 2). The presence of synthetic adulterants in herbal product poses a serious health risk to consumers. The resulting clinical consequences may be serious and sometimes life threatening. Consumers have been warned by the food and drug administration, neither to buy nor make use of natural max slimming, a product developed for weight loss. It was established by the FDA laboratory analysis that natural max slimming contains sildenafil, fluoxetine and sibutramine (3). Sibutramine was removed from the market in October 2010 (4, 5) for safety reasons such as increase blood pressure and/or pulse rate with a significant risk for patients with a history of coronary artery disease, congestive heart failure, arrhythmias, or stroke (6). Recently, sibutramine was discovered in herbal product developed for weight loss (7), and in humans, sibutramine rapidly demethylates to its pharmacologically active metabolites, N-desmethylsibutramine and N-desmethylsibutramine (8). It has structural similarities to amphetamine and is a serotonin-norepinephrine reuptake inhibitor (9). After oral consumption of Natural Max Slimming capsules, sibutramine is fast absorbed and is subjected to marked first pass metabolism (10). The primary metabolites (norsibutramine and dinorsibutramine) are responsible for the activity and obstruct the reuptake of noradrenalin and serotonin (11). The acetylated sibutramine metabolite was detected in a patient’s urine after consumption of an herbal slimming product (12). Sibutramine inhibits noradrenaline and serotonin reuptake, which leads to developed satiety following reduction in food intake. According to random placebo-controlled studies (13-17), sibutramine alongside lifestyle and dietary advice can induce dose-dependent weight loss of 5% - 10% in most patients (18, 19). Some studies have suggested that it increases serum high-density lipoprotein (HDL) cholesterol independently of weight loss (20). The drug action may be boosted in mixture with other materials which increase the concentration of norepinephrine or serotonin in the synaptic cleft or which act as serotonin agonists because of structural similarities (21). For these reasons, certain blends are in conflict with each other, mostly with several weight loss drugs, such as other SSRIs, MAO inhibitors, amphetamines, triptans, ergotamines, and some opioids (22).
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Nadir Khan
Verified Purchase Aug-24-2024Great for overall health and wellness. Wonderful product to help with weight loss.